Product Description

A novel Magnesium preparation, Magnesium L-Threonate is an oral supplement taken to raise Magnesium levels throughout body. Placed next to other commercially available Mg2+ compounds, Magnesium L-Threonate stands in a league of its own due to its relatively unmatched ability to transfer Mg2+  ions from the digestive tract into the blood, through the central nervous system, and ultimately, across the blood-brain barrier to elevate brain magnesium levels.

While Magnesium L-Threonate’s superior bioavailability has distinguished it apart from other magnesium sources, it’s reported effects on learning and memory have firmly established its locus within magnesium supplement research.  Acting on the hippocampus,  Magnesium L-Threonate is suggested to upregulate both short-term synaptic facilitation and long-term potentiation of memory acquisition by increasing activity at the glutamate NR2B subunits, NMDAR signaling, and synaptic plasticity.  A number of recent studies assessing cognitive impairment reversal in mice models have also identified Magnesium L-Threonate as a potential neuroprotective agent against synaptic loss and cognitive deficits.,

On the other end of the blood brain barrier, Mg2+ serves as an essential dietary mineral and is crucial in regulating bodily functions. It is a key element in maintaining healthy bones, blood vessels, nerves, and muscles. Furthermore, high magnesium intake is associated with greater bone density., There is a growing concern regarding widespread magnesium deficiencies in industrialized nations because these diets are generally deficient in significant magnesium food sources.

RESEARCH

  1. Slutsky, I., Abumaria, N., Wu, L., Huang, C., Zhang, L., Li, B., et al. (2010).Enhancement of learning and memory by elevating brain magnesium. Neuron,65(2), 165-177.
  2. Slutsky, I., Abumaria, N., Wu, L., Huang, C., Zhang, L., Li, B., et al. (2010).Enhancement of learning and memory by elevating brain magnesium. Neuron,65(2), 165-177.
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  4. Li, W., Yu, J., Liu, Y., Huang, X., Abumaria, N., Zhu, Y., et al. (2013). Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer’s disease mouse model. The Journal of Neuroscience, 33(19), 8423-8441.
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  8. Xu, Z., Li, L., Bao, J., Wang, Z., Zeng, J., Liu, E., et al. (2014). Elevation of brain magnesium prevents and reverses cognitive deficits and synaptic loss in Alzheimer’s disease mouse model PloS one, 9(9), e108645.
  9. Poleszak, E. (2007). Modulation of antidepressant-like activity of magnesium by serotonergic system. Journal of neural transmission, 114(9), 1129-1134.http://link.springer.com/article/10.1007/s00702-007-0714-8 (5HTP)
  10. Ichiba, H., Tamai, H., Negishi, H., Ueda, T., Kim, T., Sumida, Y., et al. (2002). Randomized controlled trial of magnesium sulfate infusion for severe birth asphyxia. Pediatrics International, 44(5), 505-509.http://onlinelibrary.wiley.com/doi/10.1046/j.1442-200X.2002.01610.x/full (DA)
  11. Lin, J., Chung, S., Lin, M., & Cheng, F. (2002). Effects of magnesium sulfate on energy metabolites and glutamate in the cortex during focal cerebral ischemia and reperfusion in the gerbil monitored by a dual-probe microdialysis technique. Life sciences, 71(7), 803-811.http://www.sciencedirect.com/science/article/pii/S0024320502017381 (Glu)
  12. Murck, H. (2002). Magnesium and affective disorders. Nutritional neuroscience,5(6), 375-389.http://www.tandfonline.com/doi/abs/10.1080/1028415021000039194 (Asp)
  13. Shimosawa, T., Takano, K., Ando, K., & Fujita, T. (2004). Magnesium inhibits norepinephrine release by blocking N-type calcium channels at peripheral sympathetic nerve endings. Hypertension, 44(6), 897-902.https://hyper.ahajournals.org/content/44/6/897.full (NE)
  14. Billard, J. M. (2006). Ageing, hippocampal synaptic activity and magnesium.Magnesium research, 19(3), 199-215. http://www.jle.com/fr/revues/mrh/e-docs/ageing_hippocampal_synaptic_activity_and_magnesium_272231/article.phtml (ACh)